Treatment of acute experimental toxoplasmosis with investigational poloxamers
نویسندگان
چکیده
منابع مشابه
Treatment of acute experimental toxoplasmosis with investigational poloxamers.
Because of the limited chemotherapeutic approaches available to treat reactivated latent Toxoplasma gondii infection manifested as toxoplasmic encephalitis in AIDS patients, investigation of novel chemotherapeutic agents is warranted. Several poloxamers (nonionic block copolymers composed of a central hydrophobic chain of polyoxypropylene flanked by two hydrophilic chains of polyoxyethylene) we...
متن کاملPathologic study of acute toxoplasmosis in experimental animals.
We studied the pathology of acute toxoplasmosis in experimental mice inoculated with RH strain tachyzoites of Toxoplasma gondii. All died from severe disseminated toxoplasmosis involving the liver, spleen and pancreas. Pathological features of acute toxoplasmosis in susceptible mice could be regarded as an excellent model for acute reactivation of Toxoplasma in the immunosuppressed host.
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چکیده ندارد.
15 صفحه اولImmunity in Experimental Toxoplasmosis*
The Beverley strain of Toxoplasma gondii produces a chronic infection in mice and other laboratory animals, causing few or no fatalities. There is an immune response to the parasite that can be detected by a variety of serological teclmiques, with however but little understandillg of the significance of the phemmenon. The purposes of these experiments were to determine: 1) the nature of this im...
متن کاملExperimental Congenital Toxoplasmosis
Pregnant mice infected with Toxoplasma by the vaginal route have been found to transmit toxoplasmosis to the placentas and fetuses in utero. The microorganism entered the blood stream of the mother from primary foci of infection in the vaginal wall and produced disseminated lesions in the labyrinth of the allantoic placenta at the same time as other peripheral maternal tissues were involved. Pl...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1993
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.37.11.2265